He has also served as a member of special review committees for the Institute of Medicine, National Research Council and for the National Science Foundation. Currently Dr. Prendergast is a member of the Board of Directors of Eli Lilly and the Infectious Disease Research Institute.
Dr. Prendergast obtained his medical degree with honors from the University of the West Indies in 1968. After internship, he attended Oxford University in England as a Rhodes Scholar where he obtained his bachelors and masters degree in Physiology. Thereafter, he was a resident in Internal Medicine at Mayo Clinic and then obtained a PhD degree in Biochemistry from the University of Minnesota in 1977. He joined the Mayo staff as a consultant and assistant professor in the Department of Pharmacology in 1978. Over the years he rose through the academic ranks at Mayo Clinic to become Professor of Pharmacology and of Biochemistry and Molecular Biology in 1986. He became the Edmond and Marion Guggenheim Professor in these same subjects in 1988. His principal areas of research have long been protein chemistry and biophysics. He has published in excess of 300 abstracts and papers. Currently, in addition to continuing research in protein biophysics, he is building research programs in drug design and discovery and computational biology.
Administratively, Dr. Prendergast has held many responsibilities within Mayo Clinic. Foremost among these are his appointments as Chair of the Department of Biochemistry and Molecular Biology, 1986-1989 inclusive; Director for Research Mayo Clinic Rochester, 1989-1992 inclusive; Mayo Clinic Rochester Board of Governors, 1989-1996 inclusive; Board of Directors, St. Marys Hospital and Methodist Hospital Rochester and Mayo Foundation Executive Committee (now called Mayo Clinic Board of Governors) 1999-2006 inclusive. He has served continuously as a member of the Mayo Board of Trustees from 1990-present. From 1994-2006 inclusive he was the Director of the Mayo Clinic Cancer Center. In November 2006 he assumed the responsibility as Director for the newly created Mayo Clinic Center for Individualized Medicine, the post he holds today.